Effects of Short-Term Varenicline Administration on Emotional and Cognitive Processing in Healthy...
Wednesday, November 7, 2012
Posted by: Natalia Gromov
Adults: A Randomized, Double-Blind, Study.
Mocking RJ, Patrick Pflanz
C, Pringle A, Parsons E, McTavish SF, Cowen PJ, Harmer CJ.
Neuropsychopharmacology. 2012 Oct 17. doi: 10.1038/npp.2012.205. [Epub ahead of
This study examined the influence of varenicline on mood and behavior
independent of smoking and smoking cessation. Subjects (n=41)were randomized to
receive either varenicline or placebo over seven days. There was no difference
between the two groups in terms of negative biases in emotional processing or
mood. However, the varenicline group scored higher on working and declarative
memory than the placebo group. The authors conclude that short-term varenicline
use did not influence negative biases in emotional processing or impulsivity in
non-smoking subjects, thereby not supporting direct depressogenic or suicidal risk
behavior-inducing effects. In contrast, varenicline may have