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NAQC Newsroom: Research

Pharmacological Treatments for Smoking Cessation

Tuesday, January 14, 2014  
Posted by: Natalia Gromov
JAMA. 2014;311(2):193-194.
Pharmacological Treatments for Smoking Cessation.
Kate Cahill; Sarah Stevens; Tim Lancaster.

This study sought to determine among the 3 first-line smoking cessation treatments (nicotine replacement therapy [NRT], bupropion, and varenicline), which is most effective in helping people who smoke achieve and maintain abstinence from smoking for at least 6 months, and what serious adverse events are associated with each? Higher rates of smoking cessation were associated with NRT (17.6%) and bupropion (19.1%) compared with placebo (10.6%). Varenicline (27.6%) and combination NRT (31.5%) (eg, patch plus inhaler) were most effective for achieving smoking cessation. None of the therapies was associated with an increased rate of serious adverse events.

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