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NAQC Newsroom: Research

Secondhand Smoke Enhances Lung Cancer Risk in Male Smokers: An Interaction.

Thursday, May 12, 2016  
Posted by: Natalia Gromov
Wentao Li, Lap Ah Tse, Joseph S. K. Au, Feng Wang, Hong Qiu, Ignatius Tak-sun Yu.
Secondhand Smoke Enhances Lung Cancer Risk in Male Smokers: An Interaction.
Nicotine Tob Res (2016)doi: 10.1093/ntr/ntw115First published online: April 23, 2016
Previous studies revealed that some indoor air pollutants and fine particle matter can interact with active smoking, enhancing lung cancer risk in smokers. Secondhand smoke, with remarkable differences from active smoking, contributes significantly to indoor air pollution and generates a considerable amount of fine particle matter, may cause a similar interaction with active smoking. Information on lifetime secondhand smoke along with active smoking and other confirmed or suspected risk factors for lung cancer was collected in this case-referent study. Odds ratios and the 95% confidence intervals of smoking status in different levels of secondhand smoke were evaluated. Potential multiplicative and additive interactions were explored.
Compared with never smokers without secondhand smoke, current smokers who were exposed to a high level of secondhand smoke demonstrated the highest odds ratio (15.13, 95% confidence interval: 8.60, 26.65), almost doubles the effect in the current smokers without secondhand smoke. Significant additive interactions between current smoking and high level of secondhand smoke were observed for all lung cancers (synergy index=1.80, 95% confidence interval: 1.02, 3.24) and the squamous carcinoma subgroup. High level of secondhand smoke exposure greatly enhanced lung cancer risk among current smokers, consistent with an additive interaction; while this interaction was predominant for the squamous carcinoma. The results provide new evidence to the rationale of promoting global smoking cessation.

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