Risk of serious adverse cardiovascular events associated with varenicline: a systematic review

1. Sonal Singh,

2. Yoon K. Loke,

3. John G. Spangler,

4. Curt D. Furberg

"There have been postmarketing reports of adverse cardiovascular events associated with the use of varenicline, a widely used smoking cessation drug. We conducted a systematic review and meta-analysis of randomized controlled trials to ascertain the serious adverse cardiovascular effects of varenicline compared with placebo among tobacco users."